Table 3 Associations between blood heavy metal concentrations and heavy metal mixture scores and women’s infertility
Main group sample (ever infertileb vs fertilec n = 1999) | Sub-group sample (ever-infertileb vs pregnantd n = 297) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Characteristics | Total N (%) or Mean (SD)a | Ever- infertileb n (%) or Mean (SD)a | Crude OR (95% CI) Model 1 | Adj OR (95% CI) Model 2 | Fully Adj OR (95% CI) Model 3 | Ever- infertileb n (%) or Mean (SD)a | Crude OR (95% CI) Model 1 | Adj OR (95% CI) Model 2 | Fully Adj OR (95% CI) Model 3 |
Lead | |||||||||
Log Transformed | -0.52 (0.62) | -0.48 (0.61) | 1.28 (0.97-1.68) | 1.69 (1.01-2.85)* | 1.75 (1.02-3.02)* | -0.48 (0.61) | 5.02 (2.73-9.23)* | 5.19 (2.14-12.59)* | 3.09 (1.22-7.85)* |
Lead quartiles | |||||||||
Q1 (Ref) (\(\le\) 0.40) | 488 (24.41%) | 52 (2.6%) | Ref | Ref | Ref | 52 (17.51%) | Ref | Ref | Ref |
Q2 (0.41 – 0.56) | 492 (24.61%) | 56 (2.8%) | 1.15 (0.70-1.89) | 1.37 (0.67-2.80) | 1.38 (0.68-2.79) | 56 (18.86%) | 3.23 (1.18-8.86)* | 2.88 (0.61-13.55) | 2.52 (0.53-12.09) |
Q3 (0.57 – 0.86) | 513 (25.66%) | 70 (3.5%) | 1.52 (1.00-2.29)* | 1.60 (0.82-3.10) | 1.61 (0.83-3.09) | 70 (23.57%) | 5.32 (2.20-12.88)* | 5.60 (1.67-18.73)* | 3.47 (1.11-10.83)* |
Q4 (> 0.86) | 506 (25.31) | 60 (3.0%) | 1.30 (0.80-2.11) | 1.71 (0.76-3.85) | 1.72 (0.75-3.95) | 60 (20.2%) | 6.71 (2.85-15.81)* | 12.62 (2.48-64.21)* | 5.26 (1.18-23.54)* |
Cadmium | |||||||||
Log Transformed | -1.16 (0.84) | -1.13 (0.84) | 1.01 (0.81-1.26) | 1.01 (0.68-1.52) | 0.94 (0.63-1.41) | -1.13 (0.84) | 1.51 (0.94-2.43) | 2.29 (0.87-6.04) | 1.90 (0.64-5.63) |
Cadmium quartiles | |||||||||
Q1 (Ref) (\(\le\) 0.18) | 469 (23.46%) | 52 (2.6%) | Ref | Ref | Ref | 52 (17.51%) | Ref | Ref | Ref |
Q2 (0.19 – 0.29) | 509 (25.46%) | 67 (3.35%) | 1.08 (0.66-1.77) | 0.65 (0.34-1.25) | 0.67 (0.35-1.27) | 67 (22.56%) | 2.06 (0.81-5.27) | 0.82 (0.16-4.05) | 0.58 (0.10-3.41) |
Q3 (0.30–0.51) | 513 (25.66%) | 53 (2.65%) | 0.87 (0.57-1.32) | 0.71 (0.38-1.33) | 0.70 (0.37-1.31) | 53 (17.85%) | 1.83 (0.76-4.41) | 0.38 (0.05-2.83) | 0.37 (0.04-3.20) |
Q4 (> 0.51) | 508 (25.41%) | 66 (3.3%) | 1.07 (0.64-1.81) | 0.95 (0.41-2.18) | 0.83 (0.36-1.94) | 66 (22.22%) | 2.19 (0.80-6.02) | 1.33 (0.09-19.70) | 0.61 (0.04-9.94) |
Mercury | |||||||||
Log Transformed | -0.29 (0.99) | -0.28 (0.96) | 1.01 (0.85-1.21) | 1.07 (0.80-1.44) | 1.02 (0.76-1.36) | -0.28 (0.96) | 1.35 (0.84-2.17) | 1.37 (0.71-2.67) | 1.38 (0.76-2.51) |
Mercury quartiles | |||||||||
Q1 (Ref) (\(\le\) 0.34) | 491 (24.56%) | 46 (2.3%) | Ref | Ref | Ref | 46 (15.49%) | Ref | Ref | Ref |
Q2 (0.34 – 0.67) | 508 (25.41%) | 72 (3.6%) | 1.69 (0.96-2.97) | 1.70 (0.76-3.81) | 1.59 (0.70-3.61) | 72 (24.24%) | 2.54 (0.90-7.17) | 2.26 (0.47-10.90) | 1.48 (0.43-5.03) |
Q3 (0.68–1.38) | 493 (24.66%) | 63 (3.15%) | 1.43 (0.82-2.49) | 1.54 (0.75-3.18) | 1.49 (0.72-3.08) | 63 (21.21%) | 1.91 (0.62 – 5.90) | 2.53 (0.54-11.78)* | 2.51 (0.60-10.59) |
Q4 (> 1.38) | 507 (25.36%) | 57 (2.85%) | 1.20 (0.66-2.17) | 0.58 (3.66-3.11) | 1.26 (0.51-3.11) | 57 (19.19%) | 1.90 (0.61 – 5.94) | 2.01 (0.40-10.20) | 1.67 (0.33-8.43) |
Weighted mixed metals | |||||||||
Log Transformed | 1.19 (0.60) | 1.22 (0.61) | 1.26 (0.94-1.69) | 1.69 (0.95 -2.99) | 1.00 (0.46—2.19) | 1.22 (0.61) | 4.60 (2.42-8.76)* | 6.21 (2.24-17.20) * | 1.30 (0.09-18.13) |
Weighted Mixed Metals quartiles | |||||||||
Q1 (Ref) (\(\le\) 2.24) | 499 (24.96%) | 53 (2.65%) | Ref | Ref | Ref | 53 (17.85%) | Ref | Ref | Ref |
Q2 (2.24–3.14) | 500 (25.01%) | 65 (3.25%) | 1.34 (0.91-1.99) | 1.58 (0.86-2.91) | 1.47 (0.80-2.71) | 65 (21.89%) | 2.66 (1.33-5.32) * | 1.86 (0.53-6.47) | 0.87 (0.18-4.30) |
Q3 (3.14–4.74) | 500 (25.01%) | 59 (2.95%) | 1.39 (0.90-2.15) | 1.31 (0.65-2.63) | 1.12 (0.56-2.25) | 59 (19.87%) | 9.62 (2.74-33.80) * | 15.87 (3.11-80.91) * | 6.92 (0.72-66.79) |
Q4 (> 4.74) | 500 (25.01%) | 61 (3.05%) | 1.29 (0.82-2.05) | 2.02 (0.89-4.75) | 1.17 (0.44-3.10) | 61 (20.54%) | 4.80 (1.77-13.03) * | 13.22 (2.39-73.17) * | 0.48 (0.01-16.32) |