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Table 3 Multivariable logistic regression analysis of risk factors associated with mother-to-child transmission of HIV at 6 weeks and at 6 months of life

From: Socio-economic, clinical and biological risk factors for mother - to – child transmission of HIV-1 in Muhima health centre (Rwanda): a prospective cohort study

 

HIV infection at 6 weeks

HIV infection at 6 months

 

(1)

(2)

Variables

adjusted OR [95% CI]

adjusted OR [95% CI]

Mother’s age

  

<=24

1.22 [0.41 - 3.64]

1.43 [0.53 - 3.89]

>24

1

1

Marital status

  

not currently married

1.42 [0.42 - 4.79]

1.55 [0.49 - 4.90]

currently married

1

1

Education attainment

  

none/primary

1.09 [0.29 - 4.08]

1.09 [0.33 - 3.63]

secondary/university education

1

1

Wealth index

  

poorest

2.07 [0.31 - 14.01]

1.37 [0.27 - 7.01]

second

0.77 [0.07 - 8.16]

0.39 [0.05 - 3.44]

middle

0.82 [0.11 - 5.90]

0.53 [0.09 - 2.94]

fourth

1.33 [0.21 - 8.32]

1.05 [0.23 - 4.91]

richest

1

1

Parity

  

primiparous

1.97 [0.65 - 5.94]

2.33 [0.84 - 6.41]

multiparous

1

1

Disclosed HIV status to partner

  

No

4.68** [1.39 - 15.77]

3.41** [1.09 - 10.65]

Yes

1

1

Place of delivery

  

home

2.98 [0.42 - 21.17]

2.21 [0.33 - 14.88]

health facility

1

1

child’s sex

  

Male

1.27 [0.49 - 3.34]

1.21 [0.49 - 2.98]

Female

1

1

Type of feeding for the child during first 6 months of life

  

mixed feeding

5.5 [0.40 - 74.82]

9.64* [0.96 - 96.62]

artificial feeding

2.45 [0.39 - 15.24]

1.99 [0.36 - 11.10]

exclusive breastfeeding

1

1

Mode of delivery

  

vaginal/instrument assisted

0.66 [0.17 - 2.57]

0.91 [0.24 - 3.40]

cesarean section

1

1

Hemoglobin

  

<11 g/dl

2.58* [0.90 - 7.40]

1.73 [0.65 - 4.62]

> = 11 g/dl

1

1

Type of ARV treatment received

  

prophylactic

1.82 [0.38 - 8.73]

1.79 [0.43 - 7.41]

curative

1

1

duration of ARV prophylaxis/treatment

  

less than 6 weeks

2.24 [0.81 - 6.16]

1.35 [0.51 - 3.57]

6 weeks or more

1

1

CD4 count

  

<350 cellules/mm3

4.83* [0.98 - 23.90]

3.82* [0.92 - 15.94]

> = 350 cellules/mm3

1

1

Viral load

  

> = 1000 copies/ml

7.30*** [2.65 - 20.08]

4.60*** [1.84 - 11.49]

<1000 copies/ml

1

1

Observations

679

675

  1. *** p < 0.01, ** p < 0.05, * p < 0.1.
  2. The following variables were considered for inclusion in the logistic regression model: mother’s age; marital status; wealth; parity; HIV status disclosure to partner; place of delivery; mode of delivery; child sex; infant feeding choice; hemoglobin; type of ARV treatment received; duration of ARV prophylaxis/treatment; CD4 count and viral load (HIV-1 RNA).
  3. Muhima health centre cohort, Kigali/Rwanda, 2007 – 2010.