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Figure 1 | Archives of Public Health

Figure 1

From: Protocol of the PSYCHOTSH study: association between neonatal thyroid stimulating hormone concentration and intellectual, psychomotor and psychosocial development at 4–5 year of age: a retrospective cohort study

Figure 1

Neonatal thyroid stimulating hormone concentration as indicator of maternal iodine deficiency. Legend: In the thyroid gland, thyroid hormones (TH) T3 and T4 are produced from association of tyrosine and iodine. Liberation of thyroid stimulating hormones (TSH) stimulates TH production and secretion. The lack of TH in the bloodstream leads to the liberation of thyrotropin-releasing hormone (TRH) from the hypothalamus. TRH stimulates the liberation of TSH by the pituitary gland. A - In situation of maternal iodine sufficiency, iodine stocks are sufficient to produce adapted amount of TH and TSH release is inhibited by negative feedback inhibition. B - In situation of maternal iodine deficiency, iodine stocks are insufficient to produce adapted quantity of TH and TSH release is maintained leading to increased TSH concentration in bloodstream.

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Archives of Public Health

ISSN: 2049-3258