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Figure 4 | Archives of Public Health

Figure 4

From: Causes of metabolic syndrome and obesity-related co-morbidities Part 1: A composite unifying theory review of human-specific co-adaptations to brain energy consumption

Figure 4

Normally functioning human NRF2 system. The nuclear factor-erythroid 2-related factor 2 (NRF2) dissociates from the Kelch-like ECH-associated protein 1 (KEAP1) and migrates to the nucleus on a wide variety of variably noxious, often pro-oxidant stimuli. The appropriate responses are then elicited and magnified via pathways sets for antioxidant, antitoxicant and repair cell protection. This principle of slightly negative stimuli causing a restorative response is denoted hormesis. In humans unknown numbers and types of micronutrients are involved in moderating and modulating the NRF2 system. Figure adapted from Jaiswal 2010 [36].

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Archives of Public Health

ISSN: 2049-3258