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Table 2 methodology of the meta-analyses on the effect of intense sweeteners on body composition.

From: Review of the nutritional benefits and risks related to intense sweeteners

First Author, year of publication (reference)

Search date

Database used

Population

Study design

Main findings

Heterogeneity

Publication bias

de la Hunty, 2006 (ref 9)

Not clear

Not clear

Healthy adults

RCT (N = 9)

Non-significant effect size of 0.221 (0.000 to 0.443) standard deviation of weight loss

Not assessed

Not assessed

Miller, 2014 (ref 16)

16 September 2013

PubMed + manual search

Healthy adults and children

RCT (N = 15)

Prospective study (N = 9)

1. RCT:

 

No evidence of publication bias (Egger’s regression test)

- on weight: -0.80 kg (–1.17 to –0.43)

I2 61 %

- on body mass index: –0.24 kg/m2 (–0.41 to –0.07)

I2 0 %

2. Prospective studies

 

- on weight: 0.02 kg (–0.01 to –0.06)

I2 92 %

- on body mass index: 0.03 kg/m2 (0.01 to 0.06)

I2 53 %