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Table 1 Case definitions for inclusion in the HUMTICK study (2016)

From: The HUMTICK study: protocol for a prospective cohort study on post-treatment Lyme disease syndrome and the disease and cost burden of Lyme borreliosis in Belgium

 

Case definition

Cohort 1: EM

- Clinical presentation of EM, confirmed by a GP

Cohort 2: Confirmed disseminated Lyme borreliosis

- Positive polymerase chain reaction (PCR) or culture

OR

- Positive serology AND at least one clinical manifestation compatible with disseminated Lyme borreliosis (confirmed by the treating physician) [12]

[see Additional file 1 for the specific description of this case definition]