Table 1 Inclusion and exclusion criteria of participants
Inclusion | Exclusion |
|---|---|
women | planned pregnancy within one year |
BMI > 27 kg/m2 | hypothyroidism |
age > 18 years | diabetes type 2 or prediabetes with medication use |
stable body weight, i.e., not varying by > 3% for at least 3 months prior to the first consultation | changes in medication regimen which can affect study outcomes (e.g. of lipid-lowering or antihypertensive agents) |
premenopausal state defined by hormonal data; FSH > 25 mU/ml and estradiol < 20 pg/ml | using drugs known to affect body weight and lipid distribution including tricyclic antidepressant agents |
willing to participate in a lifestyle based weight loss intervention (diet or exercise) | abuses alcohol or has a history of alcohol abuse, i.e., more than 2 alcoholic consumptions/day or binge drinking |
no physical dysfunctions which makes increased physical activity impossible | exclusion criteria related to MRI and CT |
able to read and understand the guidelines given by the dietician and sign the informed consent | Serious problems or diseases limiting the performance of a standardized training protocol, for example serious osteoarthritis, heart ischemia, … |