Maternal health, risk factors, and medications during pregnancy | Age 0–1 | Age 2–3 | Age 4–5 | Age 6–7 | Age 8–9 | Age 10–11 | Age 12–13 | Age 14–15 |
---|---|---|---|---|---|---|---|---|
OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | |
N = 4977 | N = 4485 | N = 4264 | N = 4088 | N = 3922 | N = 3574 | N = 3097 | N = 2960 | |
Had asthma | ||||||||
No (ref.) | ||||||||
Yes | 1.49 (1.13–1.97)* | 1.83 (1.4–2.4)** | 1.47 (1.08–1.99)Ϯ | 1.8 (1.3–2.49)** | 1.91 (1.34–2.71)** | 2.47 (1.69–3.61)** | 1.69 (1.02–2.78)Ϯ | 1.27 (0.72–2.24) |
Gestational age at birth | ||||||||
On time (37–41 weeks, ref.) | ||||||||
Early (36 weeks or less) | 1.37 (0.98–1.92) | 1.54 (1.09–2.18)Ϯ | 1.35 (0.91–2.01) | 1.48 (0.97–2.26) | 1.09 (0.66–1.78) | 0.78 (0.38–1.57) | 0.5 (0.21–1.19) | 1.08 (0.49–2.39) |
Late (42 weeks or more) | 0.63 (0.41–0.98)Ϯ | 1.00 (0.69–1.45) | 1.53 (1.02–2.30)Ϯ | 1.04 (0.67–1.63) | 1.03 (0.63–1.70) | 1.19 (0.67–2.1) | 1.25 (0.66–2.38) | 1.03 (0.50–2.1) |
Pre-pregnancy obesity | ||||||||
Healthy weight (ref.) | ||||||||
Underweight | 0.68 (0.48–0.96)Ϯ | 0.89 (0.66–1.18) | 0.87 (0.62–1.22) | 0.77 (0.54–1.09) | 0.85 (0.56–1.29) | 0.91 (0.56–1.49) | 1.21 (0.7–2.09) | 0.60 (0.29–1.24) |
Overweight | 1.19 (0.94–1.51) | 1.42 (1.15–1.74)** | 1.12 (0.89–1.42) | 1.02 (0.79–1.31) | 1.22 (0.92–1.64) | 1.1 (0.77–1.56) | 1.47 (0.97–2.25) | 1.28 (0.82–2.00) |
Obesity | 1.19 (0.91–1.56) | 1.39 (1.1–1.75)* | 1.31 (1.01–1.70)Ϯ | 1.22 (0.93–1.61) | 1.27 (0.92–1.75) | 1.57 (1.1–2.23)Ϯ | 1.41 (0.89–2.24) | 1.27 (0.79–2.06) |
Not known | 1.50 (1.20–1.89)** | 1.54 (1.23–1.93)** | 1.36 (1.05–1.76)Ϯ | 1.39 (1.06–1.82)Ϯ | 1.21 (0.89–1.65) | 1.39 (0.96–2) | 1.82 (1.18–2.83)* | 1.87 (1.17–2.99)* |
Smoking during 1st trimester | ||||||||
None (ref.) | ||||||||
< =10 cigarettes daily | 1.57 (1.17–2.1)* | 1.52 (1.15–2.00)* | 1.36 (0.99–1.86) | 1.61 (1.16–2.25)* | 1.36 (0.91–2.03) | 1.03 (0.63–1.68) | 1.3 (0.74–2.29) | 1.18 (0.62–2.24) |
11+ cigarettes daily | 1.38 (0.95–2.00) | 1.75 (1.21–2.52)* | 1.8 (1.20–2.71)* | 1.97 (1.28–3.01)* | 1.54 (0.94–2.53) | 1.56 (0.89–2.76) | 1.11 (0.53–2.32) | 2.61 (1.26–5.4)* |
Antibiotic medication | ||||||||
No (ref.) | ||||||||
Yes | 1.27 (0.99–1.62) | 1.39 (1.1–1.77)* | 1.48 (1.13–1.94)* | 1.16 (0.87–1.55) | 1.06 (0.76–1.47) | 1.29 (0.88–1.88) | 1.01 (0.61–1.67) | 0.96 (0.54–1.71) |
Anti-depressant medication | ||||||||
No (ref.) | ||||||||
Yes | 1.29 (0.76–2.17) | 1.92 (1.18–3.11)* | 1.07 (0.60–1.93) | 1.18 (0.65–2.11) | 0.69 (0.31–1.53) | 1.56 (0.76–3.2) | 1.58 (0.62–4.01) | 0.91 (0.27–3.03) |