Maternal health, Risk factors, and medications during pregnancy | Age 0–1 | Age 2–3 | Age 4–5 | Age 6–7 | Age 8–9 | Age 10–11 | Age 12–13 | Age 14–15 |
---|---|---|---|---|---|---|---|---|
OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | |
N = 4977 | N = 4485 | N = 4264 | N = 4088 | N = 3922 | N = 3574 | N = 3097 | N = 2960 | |
Had asthma | ||||||||
No (ref.) | ||||||||
Yes | 1.43 (1.06–1.94)Ϯ | 1.2 (0.88–1.63) | 1.45 (1.04–2.04)Ϯ | 1.97 (1.40–2.77)** | 1.38 (0.95–1.99) | 1.56 (1.04–2.35)Ϯ | 1.71 (1.09–2.67)Ϯ | 1.48 (0.92–2.36) |
Gestational age at birth | ||||||||
On time (37–41 weeks, ref.) | ||||||||
Early (36 weeks or less) | 0.68 (0.44–1.05) | 0.88 (0.57–1.34) | 0.90 (0.56–1.46) | 1.18 (0.71–1.95) | 0.85 (0.45–1.62) | 0.66 (0.31–1.44) | 0.53 (0.22–1.26) | 0.67 (0.28–1.62) |
Late (42 weeks or more) | 0.73 (0.47–1.14) | 0.63 (0.4–1.01) | 0.49 (0.27–0.89)Ϯ | 1.03 (0.62–1.69) | 0.97 (0.58–1.62) | 0.63 (0.35–1.14) | 0.53 (0.23–1.18) | 1.00 (0.49–2.01) |
Pre-pregnancy obesity | ||||||||
Healthy weight (ref.) | ||||||||
Underweight | 0.98 (0.73–1.33) | 0.67 (0.49–0.93)Ϯ | 0.68 (0.48–0.97)Ϯ | 0.76 (0.51–1.13) | 0.73 (0.47–1.12) | 1.14 (0.74–1.76) | 0.92 (0.55–1.54) | 0.82 (0.48–1.38) |
Overweight | 1.08 (0.86–1.36) | 1.00 (0.80–1.25) | 1.04 (0.81–1.34) | 0.99 (0.75–1.3) | 1.16 (0.88–1.53) | 1.33 (0.98–1.82) | 1.24 (0.86–1.77) | 0.91 (0.62–1.33) |
Obesity | 1.06 (0.81–1.39) | 1.14 (0.89–1.46) | 1.17 (0.89–1.56) | 1.32 (0.98–1.78) | 1.27 (0.94–1.72) | 1.24 (0.87–1.76) | 1.23 (0.82–1.85) | 1.77 (1.20–2.61)* |
Not known | 1.07 (0.84–1.36) | 0.94 (0.73–1.2) | 1.2 (0.91–1.59) | 1.06 (0.77–1.46) | 1.00 (0.72–1.4) | 1.12 (0.77–1.65) | 1.45 (0.95–2.20) | 1.02 (0.65–1.61) |
Smoking during 1st trimester | ||||||||
None (ref.) | ||||||||
Occasional/< 10 daily | 0.95 (0.67–1.35) | 1.18 (0.85–1.62) | 1.16 (0.80–1.67) | 0.83 (0.53–1.30) | 0.84 (0.54–1.32) | 0.81 (0.48–1.37) | 0.63 (0.33–1.2) | 0.56 (0.27–1.16) |
11+ daily | 0.71 (0.42–1.19) | 0.92 (0.58–1.49) | 0.76 (0.43–1.34) | 1.42 (0.82–2.44) | 0.84 (0.44–1.58) | 0.70 (0.32–1.55) | 1.09 (0.44–2.71) | 1.12 (0.52–2.42) |
Antibiotic medication | ||||||||
No (ref.) | ||||||||
Yes | 0.95 (0.73–1.26) | 1.03 (0.79–1.35) | 1.03 (0.77–1.39) | 1.30 (0.95–1.77) | 1.29 (0.94–1.78) | 1.19 (0.83–1.71) | 1.14 (0.72–1.81) | 1.35 (0.87–2.09) |
Anti-depressant medication | ||||||||
No (ref.) | ||||||||
Yes | 0.85 (0.47–1.54) | 1.71 (0.97–2.99) | 1.34 (0.72–2.48) | 1.11 (0.56–2.21) | 1.00 (0.49–2.05) | 1.03 (0.47–2.28) | 1.04 (0.37–2.91) | 0.48 (0.13–1.75) |