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Table 3 Prostatic Cancer – Spatially and Temporally Lagged Space – Time Cannabinoid Models

From: Geotemporospatial and causal inferential epidemiological overview and survey of USA cannabis, cannabidiol and cannabinoid genotoxicity expressed in cancer incidence 2003–2017: part 3 – spatiotemporal, multivariable and causal inferential pathfinding and exploratory analyses of prostate and ovarian cancers

Lagging

Parameter

Model

Lagged Variables

Parameter

estimate (C.I.)

P

Coefficient

Value

P-Value

 

Spatiotemporal Lags

     
 

Comprehensive Interactive Model - 1 Spatial & 2 Temporal Lags

 

THC Temporally Lagged

     
 

spreml(Cancer Rate ~ Age + Cigarettes * THC * CBG * CBD + AUD + Analgesics + Cocaine + Income + Five Races)

Spatial:

Income

6.59 (3.22, 9.96)

0.0001

S.D.

4.6652

 

THC, 1

Cocaine

1.82 (0.58, 3.06)

0.0039

Log.Lik

−1759.5510

 

Cannabigerol, 1

Analgesics

2.54 (0.16, 4.92)

0.0365

phi

1.9006

0.0003446

Cannabidiol, 1

Hispanic

−1.74 (−3.13, − 0.35)

0.0139

psi

0.5811

<  2.2e-16

Temporal:

Cigarettes: THC: CBD

−128.33 (− 199.73, −56.93)

0.0004

rho

− 0.8096

<  2.2e-16

Cigarettes,2

Age

−0.82 (−1.27, − 0.37)

0.0004

lambda

0.8158

< 2.2e-16

AUD,2

Cigarettes: THC

−513.27 (− 786.94, − 239.59)

0.0002

   

THC, 2

Cigarettes: THC: CBG: CBD

−39.99 (− 60.98, −19)

0.0002

   

Analgesics, 2

Cigarettes: THC: CBG

−158.61 (− 238.74, − 78.49)

0.0001

   

Cocaine, 2

THC

−2.9 (−3.93, − 1.87)

3.11e-08

   
 

Comprehensive Interactive Model - 1 Spatial & 2 Temporal Lags

     
 

Cannabidiol Temporally Lagged

     
 

spreml(Cancer Rate ~ Age + Cigarettes * THC * CBG * CBD + AUD + Analgesics + Cocaine + Income + Five Races)

Spatial:

CBD

2.08 (1.19, 2.98)

5.20e-06

S.D.

4.7079

 

THC, 1

Cocaine

2.56 (1.3, 3.81)

6.75e-05

Log.Lik

− 1758.7820

 

Cannabigerol, 1

Income

5.5 (2.26, 8.75)

0.0009

phi

5.3487

1.83e-08

Cannabidiol, 1

CBD.Spatial

1.06 (0.03, 2.1)

0.0442

psi

0.6391

< 2.2e-16

Temporal:

AIAN

−32.1 (−60.98, −3.21)

0.0294

rho

−0.7110

5.65e-16

Cigarettes,2

THC: CBG: CBD

−0.43 (− 0.81, − 0.05)

0.0257

lambda

0.6854

< 2.2e-16

AUD,2

Hispanic

−2.33 (−3.69, −0.97)

0.0008

   

Cannabidiol, 2

Cigarettes: THC: CBD

−163.72 (− 246.95, −80.48)

0.0001

   

Analgesics, 2

Cigarettes: THC: CBG: CBD

−48.79 (−73.06, − 24.51)

8.17e-05

   

Cocaine, 2

Cigarettes: THC

−651.36 (−967.53, − 335.2)

5.39e-05

   

Cigarettes: THC: CBG

−199.58 (− 291.7, − 107.47)

2.17e-05

   

Age

−1.18 (− 1.59, − 0.76)

2.36e-08

   

Spatial:

Comprehensive Interactive Model - 1 Spatial & 4 Temporal Lags

   

THC, 1

THC Temporally Lagged

     

Cannabigerol, 1

spreml(Cancer Rate ~ Age + Cigarettes * THC * CBG * CBD + AUD + Analgesics + Cocaine + Income + Five Races)

Cannabidiol, 1

THC

642.76 (165.3, 1120.23)

0.0083

S.D.

18.5723

 

Temporal:

CBG: THC

181.1 (41.49, 320.71)

0.0110

Log.Lik

− 2045.3050

 

Cigarettes,4

CBD: THC

146.56 (25.64, 267.49)

0.0175

phi

2.2917

0.0009418

AUD,4

CBG: CBD: THC

41.24 (5.57, 76.9)

0.0235

psi

0.6228

< 2.2e-16

THC, 4

Cocaine

1.42 (0.18, 2.65)

0.0247

rho

−0.8426

< 2.2e-16

Analgesics, 4

Cigarettes: CBG: CBD: THC

−192.44 (− 336.83, −48.04)

0.0090

lambda

0.8542

< 2.2e-16

Cocaine, 4

Cigarettes: CBD: THC

− 694.28 (−1189.26, − 199.3)

0.0060

   

Hispanic

−2 (−3.43, −0.58)

0.0060

   

Cigarettes: CBG: THC

− 837.5 (− 1403.64, − 271.36)

0.0037

   

Cigarettes: THC

− 3015.28 (− 4971.81, − 1058.74)

0.0025

   

Age

−1.06 (− 1.48, − 0.64)

7.82e-07

   

Spatial:

Comprehensive Interactive Model - 1 Spatial & 4 Temporal Lags

  

THC, 1

Cannabidiol Temporally Lagged

     

Cannabigerol, 1

spreml(Cancer Rate ~ Age + Cigarettes * THC * CBG * CBD + AUD + Analgesics + Cocaine + Income + Five Races)

Cannabidiol, 1

Cocaine

2.34 (1.21, 3.46)

4.53e-05

S.D.

4.7813

 

Temporal:

THC: CBG

19.63 (6.78, 32.48)

0.0028

Log.Lik

− 1492.4380

 

Cigarettes,4

THC

64.38 (22.13, 106.64)

0.0028

phi

2.2091

0.0002842

AUD,4

CBD

−1.05 (−2.04, −0.06)

0.0374

psi

0.5981

<  2.2e-16

Cannabidiol, 4

Cigarettes: THC: CBG: CBD: CBD.Spatial

−0.41 (− 0.78, − 0.05)

0.0272

rho

−0.8249

<  2.2e-16

Analgesics, 4

Cigarettes: THC: CBG

−83.75 (− 136.43, −31.07)

0.0018

lambda

0.8468

<  2.2e-16

Cocaine, 4

Hispanic

−2.26 (−3.63, − 0.9)

0.0012

   

Cigarettes: THC

−303.31 (−480.04, −126.57)

0.0008

   

Age

−1.06 (− 1.48, −0.64)

7.18e-07