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Table 7 Ovarian Cancer – Introductory Space-Time Regression

From: Geotemporospatial and causal inferential epidemiological overview and survey of USA cannabis, cannabidiol and cannabinoid genotoxicity expressed in cancer incidence 2003–2017: part 3 – spatiotemporal, multivariable and causal inferential pathfinding and exploratory analyses of prostate and ovarian cancers

Parameter

Model

Parameter

estimate (C.I.)

P

Coefficient

Value

P-Value

Cannabis Alone

  

S.D.

0.6119

 

spreml(Cancer Rate ~ Cannabis)

  

Log.Lik

− 719.3662

 

 Cannabis

−0.46 (− 0.57, − 0.35)

< 2.2e-16

phi

0.578764

5.73e-05

  

rho

−0.786241

< 2.2e-16

  

lambda

0.803723

< 2.2e-16

THC Alone

  

S.D.

0.6212

 

spreml(Cancer Rate ~ THC exposure)

  

Log.Lik

−699.7751

 

 THC exposure

−0.36 (− 0.41, − 0.31)

< 2.2e-16

phi

0.534787

5.09e-05

  

rho

−0.687793

< 2.2e-16

  

lambda

0.7014

< 2.2e-16

Cannabigerol Alone

  

S.D.

0.6175

 

spreml(Cancer Rate ~ Cannabigerol exposure)

Log.Lik

− 709.6908

 

 Cannabigerol exposure

−0.43 (−0.5, − 0.35)

< 2.2e-16

phi

0.557597

5.16e-05

  

rho

−0.738106

< 2.2e-16

  

lambda

0.754643

< 2.2e-16

Cannabidiol Alone

  

S.D.

0.6246

 

spreml(Cancer Rate ~ Cannabidiol exposure)

  

Log.Lik

−709.5827

 

 Cannabidiol exposure

0.36 (0.3, 0.42)

< 2.2e-16

phi

0.58377

4.66e-05

  

rho

−0.71922

< 2.2e-16

  

lambda

0.746991

< 2.2e-16

Additive Model - Drugs

spreml(Cancer Rate ~ Age + Cigarettes + AUD + Cannabis + Analgesics + Cocaine

S.D.

0.6667

 

 Analgesics

6.5 (0.56, 12.43)

0.0319

Log.Lik

− 682.9304

 

 AUD

4.82 (1.04, 8.59)

0.0123

phi

0.836607

3.34e-05

 Cigarettes

3.97 (2.36, 5.57)

1.27e-06

rho

−0.690814

< 2.2e-16

 Age

−0.06 (− 0.1, − 0.03)

0.0005

lambda

0.637209

< 2.2e-16

Interactive Model - Drugs

spreml(Cancer Rate ~ Age + Cigarettes * AUD * Cannabis + Analgesics + Cocaine

S.D.

0.6630

 

 Cigarettes

2.73 (0.64, 4.83)

0.0104

Log.Lik

− 681.5923

 

 Analgesics

6.83 (0.89, 12.76)

0.0243

phi

0.810219

4.21e-05

 Age

−0.05 (−0.09, − 0.02)

0.0055

rho

−0.683232

< 2.2e-16

 Cigarettes: Cannabis: AUD

−6.85 (−11.26, −2.43)

0.0024

lambda

0.631604

< 2.2e-16

Interactive Model - Comprehensive

spreml(Cancer Rate ~ Age + Cigarettes * AUD * Cannabis + Analgesics + Cocaine + Income + Five Races)

 Cigarettes

3.9 (2.04, 5.77)

4.19e-05

S.D.

0.6762

 

 Analgesics

6.42 (0.38, 12.45)

0.0373

Log.Lik

−674.869

 

 African

−0.14 (− 0.24, − 0.03)

0.0095

phi

3.3102

0.003983

 Income

−0.62 (−1.07, − 0.16)

0.0083

rho

− 0.6737

< 2.2e-16

 AIAN

−5.52 (−9.19, − 1.86)

0.0032

lambda

0.7279

< 2.2e-16

 Age

−0.07 (− 0.11, − 0.03)

0.0005

   

Interactive Cannabinoid Model - Comprehensive

spreml(Cancer Rate ~ Age + Cigarettes * THC * CBG * CBD + AUD + Income + Five Races)

 Cigarettes

3.58 (1.58, 5.58)

0.0005

S.D.

0.6448

 

 CBG

0.69 (0.32, 1.07)

0.0003

Log.Lik

−672.8832

 

 Hispanic

0.15 (0.01, 0.29)

0.0303

phi

0.686632

4.17e-05

 Cocaine

−8.04 (−15.8, −0.28)

0.0422

rho

−0.640042

1.43e-15

 AIAN

−3.78 (−7.09, −0.46)

0.0256

lambda

0.597138

< 2.2e-16

 Income

−0.73 (−1.21, − 0.26)

0.0023

   

 THC

−0.72 (−1, − 0.44)

3.87e-07