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Table 8 Ovarian Cancer – Lagged Space-Time Regression

From: Geotemporospatial and causal inferential epidemiological overview and survey of USA cannabis, cannabidiol and cannabinoid genotoxicity expressed in cancer incidence 2003–2017: part 3 – spatiotemporal, multivariable and causal inferential pathfinding and exploratory analyses of prostate and ovarian cancers

Lagged Variables

Parameter

Model

Parameter

Estimate (C.I.)

P

Coefficient

Value

P-Value

 

LAGGING WITH CANNABIS

     
 

Temporal Lagging

     
 

Comprehensive Interactive Model - 2 Temporal Lags

   
 

spreml(Cancer Rate ~ Age + Cigarettes * AUD * Cannabis + Analgesics + Cocaine + Income + Five Races)

Cigarettes, 2

Caucasian

−0.78 (− 1.49, − 0.07)

0.0306

S.D.

0.6405

 

AUD, 2

AIAN

−5.31 (− 8.92, − 1.71)

0.0039

Log.Lik

− 569.0211

 

Cannabis, 2

African

−0.18 (− 0.29, − 0.08)

0.0006

phi

0.8173

8.97e-05

Analgesics, 2

Income

−0.92 (−1.32, − 0.53)

4.50e-06

rho

− 0.6447

7.27e-16

Cocaine, 2

Cannabis

−0.5 (− 0.69, − 0.31)

2.71e-07

lambda

0.6346

< 2.2e-16

 

Comprehensive Interactive Model - 4 Temporal Lags

S.D.

0.5950

 
 

spreml(Cancer Rate ~ Age + Cigarettes * AUD * Cannabis + Analgesics + Cocaine + Income + Five Races)

Log.Lik

− 473.9722

 

Cigarettes, 4

Cocaine

13.5 (5.36, 21.65)

0.0012

phi

0.5570

0.0002

AUD, 4

Cigarettes

2.34 (0.29, 4.4)

0.0257

rho

−0.5503

8.03e-08

Cannabis, 4

Cannabis

−0.37 (− 0.57, − 0.17)

0.0003

lambda

0.6351

< 2.2e-16

Analgesics, 4

      

Cocaine, 4

      

Spatial Lagging

 

Comprehensive Interactive Model - 1 Spatial Lag

     
 

spreml(Cancer Rate ~ Age + Cigarettes * AUD * Cannabis + Analgesics + Cocaine + Income + Five Races)

Cannabis, 1

Cigarettes: Cannabis: AUD:

2.87 (1.57, 4.17)

1.44e-05

S.D.

0.6618

 

AIAN

−3.74 (−7.14, −0.33)

0.0313

Log.Lik

−674.5209

 

Cannabis

−0.45 (− 0.82, − 0.08)

0.0183

phi

0.8060

3.02e-05

Age

−0.06 (− 0.11, − 0.02)

0.0042

rho

−0.6641

< 2.2e-16

Cannabis

−0.16 (− 0.26, − 0.06)

0.0017

lambda

0.6062

< 2.2e-16

Income

−0.7 (−1.11, − 0.29)

0.0008

   

Spatiotemporal Lagging

     

Spatial Lags:

Comprehensive Interactive Model - 1 Spatial & 2 Temporal Lags

 

Cannabis, 1

In this model Cannabis was considered as both a spatially and temporally lagged variable

  

Temporal Lags:

spreml(Cancer Rate ~ Age + Cigarettes * AUD * Cannabis + Analgesics + Cocaine + Income + Five Races)

Cigarettes, 2

Cigarettes

3.9 (2.15, 5.64)

1.21e-05

S.D.

18.7670

 

AUD, 2

White

−0.97 (−1.68, − 0.25)

0.0082

Log.Lik

− 2419.9740

 

Cannabis, 2

AIAN

−6.01 (−9.63, −2.39)

0.0011

phi

0.7901

0.0001

Analgesics, 2

African

−0.2 (− 0.31, − 0.1)

0.0002

rho

− 0.6287

2.11e-14

Cocaine, 2

Cannabis

−0.52 (− 0.71, − 0.32)

2.58e-07

lambda

0.6229

< 2.2e-16

Spatial Lags:

Comprehensive Interactive Model - 1 Spatial & 4 Temporal Lags

   

Cannabis, 1

In this model Cannabis was considered as both a spatially and temporally lagged variable

S.D.

0.5877

 

Temporal Lags:

spreml(Cancer Rate ~ Age + Cigarettes * AUD * Cannabis + Analgesics + Cocaine + Income + Five Races)

Log.Lik

−474.4161

 

Cigarettes, 4

Cocaine

14.43 (6.66, 22.21)

0.0003

phi

0.5226

0.0001

AUD, 4

Income

−0.47 (−0.94, 0)

0.0492

rho

−0.5685

1.27e-08

Cannabis, 4

Cannabis

−0.32 (− 0.54, − 0.1)

0.0050

lambda

0.6437

< 2.2e-16

Analgesics, 4

      

Cocaine, 4