Table 1 Apoptosis induced after 24h exposure to cereulide (mean percentage ± SEM).

MIN6 (n=5)

INS-1E (n=4)

HepG2 (n=3)

COS (n=3)

Islets (n=3)

Medium

7.3 ± 1.3

2.5 ± 0.3

5.8 ± 0.6

1.2 ± 0.6

3.1 ± 1.2

0.05 ng/ml cereulide

5.9 ± 1.0

3.2 ± 0.5

6.6 ± 2.1

1.6 ± 0.4

3.9 ± 1.5

0.25 ng/ml cereulide

31.6 ± 5.8 *

58.1 ± 11.4 *

6.9 ± 1.5

2.9 ± 0.7

8.6 ± 2.4

0.5 ng/ml cereulide

43.6 ± 6.1 *

100.0 ± 0.0 *

11.9 ± 2.5

2.6 ± 0.6

49.2 ± 9.0

5 ng/ml cereulide

100.0 ± 0.0 *

100.0 ± 0.0 *

7.7 ± 2.3

4.3 ± 0.9

96.4 ± 3.5*