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Influence of birth weight on calcaneal bone stiffness in Belgian pre-adolescent children

Background

Several studies have shown associations between birth weight and adult bone mass. However, it is uncertain whether that influence of birth weight is already visible in childhood. This study investigated the relation between birth weight and calcaneal bone stiffness in a large sample of Belgian healthy pre-adolescent children.

Materials and methods

Participants were 827 children (3.6–11.2 y, 51.6% boys) from the Belgian cohort of the IDEFICS study. Birth weight was obtained using a parental questionnaire and quantitative ultrasound (QUS) measurements were performed to determine the calcaneal Broadband Ultrasound Attenuation (BUA), Speed of Sound (SOS) and Stiffness Index (SI) using Lunar Achilles Device.

Results

The average birth weight was 3435.7 ± 512.0 g for boys and 3256.9 ± 471.1 g for girls. The average calcaneal QUS measurements were equal to 89.6 ± 24.0 (23.3 to 153.9) dB/MHz for BUA, 1621.4 ± 49.6 (1516.3 to 1776.5) m/sec for SOS and 92.8 ± 15.6 (49.0 to 163.0) for SI. Birth weight was positively associated with BUA (r = 0.13; p = 0.002) and with SOS (r = -0.16; p < 0.001). The associations remained after correcting for age and sex in multiple regression analyses, but disappeared after correcting for anthropometric covariates.

Conclusions

Our findings suggest that birth weight, as a rough proxy indicator for genetic and environmental influences during intrauterine life, is associated with BUA and SOS in pre-adolescent children and may therefore influence the risk of osteoporosis later in life. Further studies using QUS are needed to investigate the consistency of the results of this study.

Acknowledgements

On behalf of the IDEFICS consortium.

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Correspondence to Karen Van den Bussche.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Van den Bussche, K., Michels, N., Gracia-Marco, L. et al. Influence of birth weight on calcaneal bone stiffness in Belgian pre-adolescent children. Arch Public Health 72, P5 (2014). https://doi.org/10.1186/2049-3258-72-S1-P5

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Keywords

  • Birth Weight
  • Stiffness Index
  • Quantitative Ultrasound
  • Parental Questionnaire
  • Average Birth Weight