Skip to main content

Volume 73 Supplement 1

Methods in Epidemiology Symposium

Altered neonatal cord blood oxylipidome in association with exposure to particulate matter in the early life environment

Background and aims

As part of the lipidome, oxylipins are bioactive lipid compounds originating from oxidation of different fatty acids. We studied oxylipin profiles in cord blood as part of the lipidome in early life in association with in utero exposure to particulate air pollution.


Oxylipins were extracted from 197 cord blood plasma samples from the ENVIRONAGE (ENVIRonmental influence ON AGEing in early life) birth cohort in Belgium. Thirty-seven specific oxylipins reflecting the cyclooxygenase (COX), lipoxygenase (5-LOX and 12/15-LOX) and cytochrome P450 (CYP) metabolic pathways were quantified by ultra-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry (UPLC-ESI-MS/MS). Principal component analysis and multiple regression models were applied to associate oxylipin pathways as well as individual metabolites with in utero PM2.5 exposure, while adjusting for newborns gender, gestational duration, maternal age, maternal smoking status, maternal BMI, and cord blood total cholesterol and HDL levels.


PM2.5 exposure during pregnancy averaged (25th-75th percentile) 15.7 (13.5-17.5) μg/m3. Six metabolites combined in a principal component (PC), representing the 5-LOX pathway was positively associated with PM2.5 exposure during the entire (? = 0.11; 95% CI: 0.03, 0.20; p = 0.01) and second trimester of pregnancy (β = 0.06; 95% CI: 0.01, 0.10; p = 0.01). Eleven metabolites combined in a PC representing the 12/15-LOX pathway was positively associated with PM2.5 during the second trimester of pregnancy (β = 0.09; 95% CI: 0.03, 0.15; p = 0.006). No associations were found for the COX and CYP pathways.


In utero exposure to particulate matter was associated with the lipoxygenase pathways (5-LOX and 15-LOX) in newborns. These changes at the level of the lipidome indicate an altered inflammatory state of the newborn at birth induced by air pollution during in utero life.

Author information

Authors and Affiliations


Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Martens, D., Gouveia-Figueira, S., Madhloum, N. et al. Altered neonatal cord blood oxylipidome in association with exposure to particulate matter in the early life environment. Arch Public Health 73 (Suppl 1), O5 (2015).

Download citation

  • Published:

  • DOI: