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Archives of Public Health

Volume 73 Supplement 1

Methods in Epidemiology Symposium

Open Access

AURORA: Bariatric surgery registration in women of reproductive age - a multicenter prospective cohort study

  • Goele Jans1,
  • Christophe Matthys2,
  • Matthias Lannoo2,
  • Bart Van der Schueren2,
  • Bruno Dillemans3,
  • Luc Lemmens4,
  • Jean-Pierre Saey5,
  • Yves Van Nieuwenhove6,
  • Ben De Becker7,
  • Pascale Grandjean5,
  • Hilde Logghe8,
  • Kristien Roelens6,
  • Anne Loccufier3,
  • Johan Verhaeghe2 and
  • Roland Devlieger2
Archives of Public HealthThe official journal of the Belgian Public Health Association201573(Suppl 1):P45

Published: 17 September 2015


Bariatric surgery has become the most successful long-term treatment of severe obesity, illustrated by almost 469,000 performed procedures worldwide in 2013. Women aged 18-45 years represent the major part of the bariatric population. A long-term follow-up, starting before surgery until a subsequent pregnancy and postpartum period, is needed to study reproduction outcomes in order to fill knowledge gaps and provide a scientific base for clinical guidelines.


This multicenter prospective cohort study aims to examine the impact of bariatric surgery on reproduction outcomes. Women aged 18-45 years are invited to participate at 4 possible inclusion moments: 1) pre-operatively, 2) post-operatively, 3) before 15 weeks of pregnancy and 4) in the early postpartum period. Depending on the time of inclusion, data is collected pre-operatively, 3 weeks and 3, 6 and 12 months post-operatively and during the first, second and third trimester of pregnancy, at delivery, weekly until 6 weeks postpartum and finally at 6 months postpartum. Online questionnaires (contraceptive use, sexuality, menstrual cycle, intention of becoming pregnant, diet, physical activity, psycho-social health and nutritional supplement intake) are distributed on the different measuring moments. Fasting blood samples are collected to determine the nutritional status, measuring vitamin A, D, E, K, B-1, B-12 and folate, albumin, total protein, hemoglobin, hematocrit, iron, ferritin, transferrin (saturation), prothrombin time, activated partial prothrombin time, magnesium, calcium and zinc. Participants will be weighted every measurement point. Ultrasounds and pregnancy outcomes are reported every trimester of pregnancy. Breast milk samples of 5 ml are collected weekly from after birth until the routine 6 week postpartum consultation in order to examine the milk macronutrient composition.


AURORA is a unique multicenter cohort study and might be of great value for the development of guidelines and recommendations in order to optimize clinical care in these women.

Authors’ Affiliations

KU Leuven, Leuven, Belgium
KU Leuven/University of Leuven, Leuven, Belgium
AZ St-Jan, Bruges, Belgium
AZ St-Nikolaas, St-Niklaas, Belgium
CHR Mons-Hainaut, Mons-Hainaut, Belgium
UZ Gent, Gent, Belgium
AZ St-Augustinus, Wilrijk, Belgium
AZ St-Lucas, Bruges, Belgium


© Jans et al. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.


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