Maternal health, Risk factors, and medications during pregnancy | Age 2–3 | Age 4–5 | Age 6–7 | Age 8–9 | Age 10–11 | Age 12–13 | Age 14–15 |
---|---|---|---|---|---|---|---|
OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | |
N = 4485 | N = 4264 | N = 4088 | N = 3922 | N = 3574 | N = 3097 | N = 2960 | |
Had Asthma | |||||||
No (ref.) | |||||||
Yes | 2.22 (1.65–3.00)** | 2.34 (1.77–3.10)** | 2.58 (1.94–3.44)** | 2.42 (1.83–3.2)** | 2.64 (1.96–3.56)** | 2.9 (2.09–4.02)** | 2.5 (1.78–3.52)** |
Gestational age at birth | |||||||
On time (37–41 weeks, ref.) | |||||||
Early (36 weeks or less) | 1.39 (0.88–2.18) | 1.3 (0.88–1.91) | 1.05 (0.71–1.55) | 1.29 (0.88–1.89) | 1.08 (0.71–1.64) | 0.82 (0.50–1.35) | 0.87 (0.54–1.41) |
Late (42 weeks or more) | 0.79 (0.49–1.28) | 1 (0.66–1.52) | 0.88 (0.59–1.32) | 0.83 (0.56–1.24) | 0.84 (0.55–1.28) | 1.05 (0.66–1.67) | 0.97 (0.62–1.52) |
Pre-pregnancy obesity | |||||||
Healthy weight (ref.) | |||||||
Underweight | 0.98 (0.68–1.4) | 0.85 (0.61–1.17) | 0.85 (0.63–1.16) | 0.86 (0.64–1.16) | 0.82 (0.60–1.12) | 0.87 (0.62–1.21) | 0.91 (0.65–1.28) |
Overweight | 1.37 (1.06–1.78)Ϯ | 1.29 (1.03–1.62)Ϯ | 1.27 (1.03–1.58)Ϯ | 1.29 (1.04–1.59)Ϯ | 1.27 (1.02–1.59)Ϯ | 1.22 (0.96–1.56) | 1.24 (0.97–1.58) |
Obesity | 1.54 (1.16–2.05)* | 1.48 (1.15–1.89)* | 1.39 (1.09–1.78)* | 1.42 (1.12–1.80)* | 1.41 (1.09–1.81)* | 1.21 (0.92–1.59) | 1.27 (0.97–1.67) |
Not known | 1.42 (1.08–1.88)Ϯ | 1.33 (1.04–1.7)Ϯ | 1.34 (1.05–1.71)Ϯ | 1.36 (1.07–1.72)Ϯ | 1.62 (1.26–2.09)** | 1.65 (1.25–2.19)** | 1.69 (1.26–2.25)** |
Smoking during 1st trimester | |||||||
None (ref.) | |||||||
< =10 cigarettes daily | 1.10 (0.78–1.54) | 0.95 (0.69–1.30) | 1.05 (0.77–1.43) | 0.98 (0.72–1.35) | 1.08 (0.77–1.51) | 1.03 (0.71–1.5) | 0.88 (0.59–1.32) |
11+ cigarettes daily | 1.67 (1.1–2.54)Ϯ | 1.84 (1.24–2.72)* | 1.66 (1.12–2.47)Ϯ | 1.54 (1.01–2.34)Ϯ | 1.6 (1.02–2.52)Ϯ | 1.58 (0.97–2.57) | 1.88 (1.14–3.09)Ϯ |
Antibiotic medication | |||||||
No (ref.) | |||||||
Yes | 1.20 (0.89–1.60) | 1.09 (0.84–1.41) | 1.19 (0.91–1.55) | 1.15 (0.89–1.49) | 1.18 (0.90–1.54) | 1.01 (0.75–1.36) | 1.02 (0.75–1.38) |
Anti-depressant medication | |||||||
No (ref.) | |||||||
Yes | 0.95 (0.49–1.85) | 1.30 (0.74–2.29) | 1.83 (1.07–3.12)Ϯ | 1.27 (0.71–2.26) | 1.49 (0.82–2.71) | 1.3 (0.65–2.60) | 0.50 (0.21–1.20) |