Maternal health, Risk factors, and medications during pregnancy | Age 2–3 | Age 4–5 | Age 6–7 | Age 8–9 | Age 10–11 | Age 12–13 | Age 14–15 |
---|---|---|---|---|---|---|---|
OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | |
N = 4485 | N = 4264 | N = 4088 | N = 3922 | N = 3574 | N = 3097 | N = 2960 | |
Had asthma | |||||||
No (ref.) | |||||||
Yes | 2.53 (1.85–3.46)** | 3.29 (2.47–4.40)** | 3.32 (2.45–4.50)** | 2.75 (2.03–3.73)** | 3.74 (2.72–5.15)** | 3.18 (2.22–4.56)** | 2.63 (1.79–3.87)** |
Gestational age at birth | |||||||
On time (37–41 weeks, ref.) | |||||||
Early (36 weeks or less) | 1.26 (0.74–2.14) | 1.23 (0.77–1.95) | 1.00 (0.63–1.58) | 0.81 (0.48–1.37) | 0.63 (0.34–1.17) | 0.65 (0.32–1.34) | 0.72 (0.34–1.53) |
Late (42 weeks or more) | 0.83 (0.49–1.42) | 1.03 (0.63–1.69) | 1.21 (0.75–1.96) | 0.99 (0.60–1.63) | 1.30 (0.77–2.21) | 1.11 (0.63–1.95) | 1.30 (0.73–2.30) |
Pre-pregnancy obesity | |||||||
Healthy weight | |||||||
Underweight | 0.81 (0.53–1.23) | 0.73 (0.48–1.1) | 0.91 (0.62–1.32) | 0.99 (0.69–1.44) | 0.94 (0.62–1.42) | 1.02 (0.66–1.58) | 0.98 (0.61–1.55) |
Overweight | 1.37 (1.03–1.82)Ϯ | 1.20 (0.92–1.56) | 1.25 (0.96–1.63) | 1.34 (1.03–1.74)Ϯ | 1.3 (0.98–1.73) | 1.37 (1.00–1.89) | 1.18 (0.84–1.68) |
Obesity | 1.50 (1.10–2.06)Ϯ | 1.39 (1.04–1.86)Ϯ | 1.55 (1.15–2.09)* | 1.40 (1.04–1.87)Ϯ | 1.29 (0.94–1.78) | 1.31 (0.92–1.86) | 1.37 (0.96–1.96) |
Not known | 1.40 (1.04–1.89)Ϯ | 1.23 (0.93–1.64) | 1.46 (1.09–1.96)Ϯ | 1.57 (1.18–2.09)* | 1.78 (1.30–2.44)** | 1.47 (1.03–2.11)Ϯ | 1.41 (0.97–2.04) |
Smoking during 1st trimester | |||||||
None (ref.) | |||||||
< =10 cigarettes daily | 0.98 (0.66–1.44) | 0.94 (0.64–1.38) | 1.01 (0.68–1.52) | 1.14 (0.77–1.7) | 1.22 (0.77–1.91) | 1.23 (0.76–1.99) | 0.77 (0.44–1.36) |
11+ cigarettes daily | 1.53 (0.96–2.43) | 1.91 (1.23–2.96)* | 1.71 (1.08–2.71)Ϯ | 1.40 (0.83–2.36) | 1.78 (1.06–2.99)Ϯ | 1.49 (0.84–2.65) | 1.70 (0.89–3.25) |
Antibiotic medication | |||||||
No (ref.) | |||||||
Yes | 1.22 (0.89–1.68) | 1.14 (0.85–1.54) | 1.27 (0.95–1.72) | 1.19 (0.88–1.61) | 1.19 (0.86–1.64) | 0.89 (0.61–1.31) | 0.93 (0.62–1.39) |
Anti-depressant medication | |||||||
No (ref.) | |||||||
Yes | 0.95 (0.47–1.95) | 1.33 (0.7–2.53) | 1.53 (0.84–2.8) | 0.86 (0.41–1.83) | 1.48 (0.70–3.12) | 1.43 (0.61–3.38) | 0.90 (0.32–2.55) |