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Table 2 Multivariable analysis of factors associated with poor TB treatment outcomes at Kilifi County from 2012 to 2019

From: Tuberculosis poor treatment outcomes and its determinants in Kilifi County, Kenya: a retrospective cohort study from 2012 to 2019

  First 3 months Last 3 months
  Adjusted HR (95%CI) P-value Adjusted HR (95%CI) P-value
Sex
  Male a   Reference  
  Female a   0.83 (0.70–0.97) 0.02
Age in years
  18 to 30 years a   Reference  
  31 to 40 years a   0.97 (0.80–1.19) 0.80
  41 to 50 years a   0.95 (0.75–1.20) 0.66
  51 + years a   1.26 (1.02–1.55) 0.03
Patient type
  New cases a   Reference  
  Re-treatment cases a   1.57 (1.28–1.93) <0.001
Nutrition status
  Undernourished 0.96 (0.86–1.07) 0.47 a  
  Normal BMI Reference   a  
  Overweight 0.85 (0.73–0.98) 0.04 a  
HIV status
  HIV uninfected Reference   Reference  
  HIV infected on ARVS 1.08 (0.98–1.20) 0.13 1.65 (1.39–1.96) <0.001
  HIV infected not on ARVS 1.72 (1.28–2.30) <0.001 2.56 (1.39–4.72) 0.003
  Unknown HIV status 1.12 (0.74–1.68) 0.60 0.92 (0.34–2.46) 0.86
  Underlying conditions a   2.24 (1.41–3.54) 0.001
TB diagnosis
  Bacteriologically confirmed a   Reference  
  Clinical signs a   0.82 (0.70–0.97) 0.02
Year of starting treatment
  2012 Reference   Reference  
  2013 1.56 (1.20–2.02) 0.001 1.37 (0.95–1.98) 0.10
  2014 1.55 (1.22–1.96) <0.001 1.67 (1.16–2.40) 0.005
  2015 1.58 (1.24–2.00) <0.001 2.24 (1.57–3.20) <0.001
  2016 1.40 (1.11–1.76) 0.004 3.06 (2.17–4.31) <0.001
  2017 1.79 (1.42–2.25) <0.001 2.80 (1.99–3.94) <0.001
  2018 1.93 (1.55–2.39) <0.001 2.48 (1.77–3.47) <0.001
  2019 1.59 (1.27–1.99) <0.001 2.30 (1.62–3.27) <0.001
AUCs (95% CI) 0.60 (0.58–0.62) 0.64 (0.63–0.65)
  1. avariables were not selected for inclusion in multivariable model