Table 1 Numbers, calculated rates, extreme values, significance and e-values for tobacco

Lung

656,647

677,158,296

961,061

1,357,237,072

96.9710

70.8101

1.3695 (1.3652, 1.3738)

0.2696 (0.2673, 0.2719)

0.1094 (0.1083, 0.1106)

38,848.04

< 2.2E-320

2.07996

2.07042

Vulva.&.Vagina

29,220

669,780,121

46,922

1,355,478,100

4.3626

3.4616

1.2603 (1.242, 1.2788)

0.2065 (0.1948, 0.218)

0.0792 (0.0741, 0.0844)

967.76

8.12E-213

1.83294

1.79018

Kidney

158,246

677,656,697

273,505

1,357,924,628

23.3520

20.1414

1.1594 (1.1522, 1.1666)

0.1375 (0.1321, 0.1428)

0.0504 (0.0482, 0.0525)

2196.42

< 2.2E-320

1.58920

1.57099

Colorectal

389,377

677,425,566

691,163

1,357,506,970

57.4790

50.9141

1.1289 (1.1245, 1.1334)

0.1142 (0.1107, 0.1176)

0.0411 (0.0398, 0.0425)

3665.82

< 2.2E-320

1.51027

1.49851

Cervix

32,835

677,782,108

58,296

1,358,139,837

4.8445

4.2923

1.1286 (1.1135, 1.144)

0.114 (0.1019, 0.1259)

0.0411 (0.0364, 0.0457)

307.90

2.99E-69

1.50963

1.46890

Oropharynx

115,204

677,699,739

207,304

1,357,990,829

16.9993

15.2655

1.1136 (1.1056, 1.1216)

0.102 (0.0955, 0.1084)

0.0364 (0.0339, 0.0389)

857.67

6.63E-189

1.46916

1.44720

Esophagus

41,573

649,871,778

80,904

1,358,117,229

6.3972

5.9571

1.0739 (1.0612, 1.0867)

0.0688 (0.0577, 0.0797)

0.0233 (0.0194, 0.0273)

139.56

1.34E-32

1.35552

1.31619

Penis

4438

553,731,268

8680

1,190,377,950

0.8015

0.7292

1.0992 (1.0601, 1.1397)

0.0902 (0.0567, 0.1225)

0.0305 (0.0186, 0.0423)

26.28

2.95E-07

1.42936

1.31263

All_Cancer

4,097,024

673,717,919

7,884,694

1,350,313,439

608.1215

583.9159

1.0415 (1.0402, 1.0427)

0.0396 (0.0384, 0.0407)

0.0135 (0.0131, 0.0139)

4422.11

< 2.2E-320

1.24833

1.24383

Brain

53,859

677,761,084

103,713

1,358,094,420

7.9466

7.6366

1.0406 (1.0298, 1.0515)

0.039 (0.0289, 0.049)

0.0133 (0.0098, 0.0168)

56.11

6.85E-14

1.24608

1.20501

Bladder

185,938

677,629,005

366,650

1,357,831,483

27.4395

27.0026

1.0162 (1.0105, 1.0219)

0.0159 (0.0104, 0.0214)

0.0054 (0.0035, 0.0072)

31.77

1.74E-08

1.14438

1.11363

CML

16,596

669,959,025

32,750

1,355,621,500

2.4772

2.4159

1.0254 (1.0064, 1.0447)

0.0248 (0.0064, 0.0428)

0.0083 (0.0021, 0.0145)

6.93

0.008498621

1.18675

1.08680

Hodgkins

18,865

677,796,078

37,284

1,358,160,849

2.7833

2.7452

1.0139 (0.9963, 1.0318)

0.0137 (−0.0037, 0.0308)

0.0046 (− 0.0013, 0.0104)

2.38

0.122840457

1.13251

1.00

AML

40,264

677,774,679

80,681

1,358,117,452

5.9406

5.9407

1 (0.9881, 1.012)

0 (− 0.012, 0.0119)

0 (− 0.004, 0.004)

0.00

0.997775002

1.00414

NA

Prostate

479,151

677,335,792

972,452

1,357,225,681

70.7405

71.6500

0.9873 (0.9839, 0.9907)

−0.0128 (− 0.0164, − 0.0094)

− 0.0042 (− 0.0054, − 0.0031)

52.35

4.64E-13

1.12692

NA

Myeloma

54,005

677,760,938

110,422

1,358,087,711

7.9681

8.1307

0.98 (0.97, 0.9901)

−0.0204 (− 0.031, − 0.01)

−0.0067 (− 0.0101, − 0.0033)

14.80

1.20E-04

1.16470

NA

Breast

576,439

677,238,504

1,180,798

1,357,017,335

85.1161

87.0142

0.9782 (0.9751, 0.9813)

−0.0223 (− 0.0255, − 0.0191)

−0.0073 (− 0.0083, − 0.0063)

188.27

4.37E-43

1.17320

NA

Pancreas

112,830

677,702,113

231,985

1,357,966,148

16.6489

17.0833

0.9746 (0.9677, 0.9815)

−0.0261 (− 0.0334, − 0.0188)

−0.0085 (− 0.0109, − 0.0062)

50.36

1.28E-12

1.18970

NA

NH_Lymphoma

165,126

677,649,817

344,785

1,357,853,348

24.3675

25.3919

0.9597 (0.954, 0.9653)

−0.042 (− 0.0482, − 0.0359)

−0.0136 (− 0.0155, − 0.0117)

189.31

2.64E-43

1.25130

NA

Ovary

52,311

677,762,632

111,212

1,358,086,921

7.7181

8.1889

0.9425 (0.9328, 0.9524)

−0.061 (− 0.0721, − 0.05)

−0.0195 (− 0.0229, − 0.0161)

124.74

2.56E-29

1.31537

NA

CLL

44,694

677,770,249

95,596

1,358,102,537

6.5942

7.0389

0.9368 (0.9264, 0.9474)

−0.0674 (− 0.0795, − 0.0555)

−0.0215 (− 0.0251, − 0.0178)

129.75

2.06E-30

1.33573

NA

Testis

18,973

677,795,970

40,700

1,358,157,433

2.7993

2.9967

0.9341 (0.9182, 0.9504)

−0.0705 (− 0.0891, − 0.0522)

−0.0224 (− 0.028, − 0.0168)

60.10

8.99E-15

1.34525

NA

ALL

11,779

601,068,358

27,611

1,255,633,450

1.9596

2.1990

0.8911 (0.8721, 0.9106)

−0.1221 (− 0.1466, − 0.0982)

−0.0365 (− 0.0432, − 0.0299)

109.78

4.94E-26

1.49237

NA

Thyroid

97,552

677,717,392

225,182

1,357,972,951

14.3941

16.5822

0.868 (0.8616, 0.8746)

−0.152 (− 0.1607, − 0.1434)

−0.0459 (− 0.0483, − 0.0436)

1365.04

3.47E-300

1.57041

NA

Stomach

56,389

677,758,554

136,254

1,358,061,879

8.3199

10.0330

0.8293 (0.8212, 0.8374)

−0.2059 (− 0.2178, − 0.1941)

−0.0603 (− 0.0633, − 0.0572)

1401.96

1.05E-306

1.70413

NA

Kaposi

2824

277,888,455

10,419

794,070,351

1.0161

1.3122

0.7744 (0.7429, 0.8073)

−0.2913 (− 0.3461, − 0.2387)

−0.0621 (− 0.0716, − 0.0527)

146.00

6.53E-34

1.90462

NA

Liver

68,272

677,746,671

178,617

1,358,019,516

10.0733

13.1528

0.7659 (0.7591, 0.7727)

−0.3057 (− 0.3172, − 0.2942)

−0.0845 (− 0.0872, − 0.0819)

3534.82

< 2.2E-320

1.93740

NA

Melanoma

83,366

677,731,577

550,065

1,357,648,068

12.3008

40.5160

0.3036 (0.3014, 0.3058)

−2.2928 (− 2.3169, − 2.2689)

−0.3018 (− 0.303, − 0.3005)

115,616.10

< 2.2E-320

6.04057

NA